|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, CCT2, 99D8.1, CCTB|
|Target/Specificity||Detects an ~55 kD protein, corresponding to the apparent molecular mass of TCP-1beta on SDS-PAGE immunoblots. This antibody does not react with human Hsp60 nor with E. coli GroEL proteins.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. For maximum product recovery, after thawing, centrifuge the product vial before removing cap.|
|Precautions||CCT2 / CCT Beta Antibody (clone PK/8/4/4i/2f) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.|
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Provided below are standard protocols that you may find useful for product applications.
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Won K.-A.,et al.Mol. Cell. Biol. 18:7584-7589(1998).
Xin Y.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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