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CCT2 / CCT Beta Antibody (clone PK/8/4/4i/2f)
Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P78371 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Bovine, Dog |
| Host | Rat |
| Clonality | Monoclonal |
| Clone Names | PK/8/4/4i/2f |
| Calculated MW | 57kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 10576 |
|---|---|
| Other Names | T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, CCT2, 99D8.1, CCTB |
| Target/Specificity | Detects an ~55 kD protein, corresponding to the apparent molecular mass of TCP-1beta on SDS-PAGE immunoblots. This antibody does not react with human Hsp60 nor with E. coli GroEL proteins. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. For maximum product recovery, after thawing, centrifuge the product vial before removing cap. |
| Precautions | CCT2 / CCT Beta Antibody (clone PK/8/4/4i/2f) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCT2 |
|---|---|
| Synonyms | 99D8.1, CCTB |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
| Cellular Location | Cytoplasm. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References
Won K.-A.,et al.Mol. Cell. Biol. 18:7584-7589(1998).
Xin Y.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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