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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   CASP9 / Caspase 9 Antibody (aa299-318)   

CASP9 / Caspase 9 Antibody (aa299-318)

Rabbit Polyclonal Antibody

     
  • IF - CASP9 / Caspase 9 Antibody (aa299-318) ALS12942
    Immunofluorescence of Caspase-9 in K562 cells with Caspase-9 antibody at 20 ug/ml.
  • WB - CASP9 / Caspase 9 Antibody (aa299-318) ALS12942
    Western blot of caspase-9 in HeLa whole cell lysate with Caspase-9 antibody at 1:1000 dilution.
  • ICC - CASP9 / Caspase 9 Antibody (aa299-318) ALS12942
    Immunocytochemical staining of K562 cells using Caspase-9 antibody at 2 µg/ml.
  • IHC - CASP9 / Caspase 9 Antibody (aa299-318) ALS12942
    Anti-Caspase 9 antibody IHC of human spleen.
  • IHC - CASP9 / Caspase 9 Antibody (aa299-318) ALS12942
    Anti-Caspase 9 antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession P55211
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (5 µg/ml), WB (1:1000-1:2000),
Additional Information
Gene ID 842
Other Names Caspase-9, CASP-9, 3.4.22.62, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6
Target/Specificity peptide corresponding to amino acids 299 to 318 of human caspase-9
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCASP9 / Caspase 9 Antibody (aa299-318) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP9
Synonyms MCH6
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Tissue Location Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Research Areas
Citations (0)

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Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).

References

Duan H.,et al.J. Biol. Chem. 271:16720-16724(1996).
Srinivasula S.M.,et al.J. Biol. Chem. 271:27099-27106(1996).
Hadano S.,et al.Mamm. Genome 10:757-760(1999).
Srinivasula S.M.,et al.Cancer Res. 59:999-1002(1999).
Izawa M.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12942
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