|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Xenopus, Bovine, Guinea Pig, Dog, Drosophila|
|Dilution||IHC-P (10 µg/ml), WB (1 µg/ml),|
|Other Names||Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||JUN / c-Jun Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Hattori K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988).
Bohmann D.,et al.Science 238:1386-1392(1987).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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