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>   home   >   Products   >   Primary Antibodies   >   SPN / CD43 Antibody (clone 84-3C1)   

SPN / CD43 Antibody (clone 84-3C1)

Mouse Monoclonal Antibody

     
  • IHC - SPN / CD43 Antibody (clone 84-3C1) ALS12960
    Anti-SPN / CD43 antibody IHC of human spleen.
  • IHC - SPN / CD43 Antibody (clone 84-3C1) ALS12960
    Anti-SPN / CD43 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession P16150
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 84-3C1
Calculated MW 40322 Da
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 6693
Other Names Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43
Reconstitution & Storage Store at 4°C, avoid repeated freeze thaw cycles.
PrecautionsSPN / CD43 Antibody (clone 84-3C1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPN
Synonyms CD43
Function Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T- cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter- receptor for SIGLEC1 (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000250|UniProtKB:P15702}
Tissue Location Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas
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$ 425.00
Cat# ALS12960
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