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ITGB4 / Integrin Beta 4 Antibody (clone 439-9B)

Rat Monoclonal Antibody

     
  • IHC - ITGB4 / Integrin Beta 4 Antibody (clone 439-9B) ALS12961
    Anti-Integrin Beta 4 antibody IHC of human placenta.
  • IHC - ITGB4 / Integrin Beta 4 Antibody (clone 439-9B) ALS12961
    Anti-Integrin Beta 4 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-Fr, Flo
Primary Accession P16144
Reactivity Human
Host Rat
Clonality Monoclonal
Clone Names 439-9B
Calculated MW 202kDa
Dilution IHC-Fr, IHC-P (20 µg/ml),
Additional Information
Gene ID 3691
Other Names Integrin beta-4, GP150, CD104, ITGB4
Reconstitution & Storage Store at 4°C, avoid repeated freeze thaw cycles.
PrecautionsITGB4 / Integrin Beta 4 Antibody (clone 439-9B) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGB4
Function Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes
Tissue Location Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach
Research Areas
Citations (0)

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Background

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

References

Suzuki S.,et al.EMBO J. 9:757-763(1990).
Hogervorst F.,et al.EMBO J. 9:765-770(1990).
Tamura R.N.,et al.J. Cell Biol. 111:1593-1604(1990).
Pulkkinen L.,et al.Lab. Invest. 76:823-833(1997).
Iacovacci S.,et al.Mamm. Genome 8:448-450(1997).

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$ 395.00
Cat# ALS12961
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