|Application ||WB, IHC-P, IHC-Fr, Flo|
|Dilution||IHC-Fr, IHC-P (20 µg/ml),|
|Other Names||Integrin beta-4, GP150, CD104, ITGB4|
|Reconstitution & Storage||Store at 4°C, avoid repeated freeze thaw cycles.|
|Precautions||ITGB4 / Integrin Beta 4 Antibody (clone 439-9B) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes|
|Tissue Location||Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach|
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Provided below are standard protocols that you may find useful for product applications.
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Suzuki S.,et al.EMBO J. 9:757-763(1990).
Hogervorst F.,et al.EMBO J. 9:765-770(1990).
Tamura R.N.,et al.J. Cell Biol. 111:1593-1604(1990).
Pulkkinen L.,et al.Lab. Invest. 76:823-833(1997).
Iacovacci S.,et al.Mamm. Genome 8:448-450(1997).
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