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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD163 Antibody (clone GHI/61)   

CD163 Antibody (clone GHI/61)

Mouse Monoclonal Antibody

     
  • IHC - CD163 Antibody (clone GHI/61) ALS12962
    Anti-CD163 antibody IHC of human spleen.
  • IHC - CD163 Antibody (clone GHI/61) ALS12962
    Anti-CD163 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession Q86VB7
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names GHI/61
Calculated MW 125kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 9332
Other Names Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130
Target/Specificity CD163
Reconstitution & Storage Store at 4°C, avoid repeated freeze thaw cycles.
PrecautionsCD163 Antibody (clone GHI/61) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD163
Synonyms M130
Function Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Cellular Location Soluble CD163: Secreted
Tissue Location Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Research Areas
Citations (0)

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Background

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

References

Law S.K.A.,et al.Eur. J. Immunol. 23:2320-2325(1993).
Ritter M.,et al.Biochem. Biophys. Res. Commun. 260:466-474(1999).
Welch S.-K.W.,et al.Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Droste A.,et al.Biochem. Biophys. Res. Commun. 256:110-113(1999).

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$ 395.00
Cat# ALS12962
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