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NCOA3 / SRC-3 / AIB1 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9Y6Q9 |
| Reactivity | Human, Hamster, Monkey, Pig, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 155kDa |
| Dilution | IHC-P (3.75 µg/ml) |
| Gene ID | 8202 |
|---|---|
| Other Names | Nuclear receptor coactivator 3, NCoA-3, 2.3.1.48, ACTR, Amplified in breast cancer 1 protein, AIB-1, CBP-interacting protein, pCIP, Class E basic helix-loop-helix protein 42, bHLHe42, Receptor-associated coactivator 3, RAC-3, Steroid receptor coactivator protein 3, SRC-3, Thyroid hormone receptor activator molecule 1, TRAM-1, NCOA3, AIB1, BHLHE42, RAC3, TRAM1 |
| Target/Specificity | Human NCOA3. This antibody is expected to recognise both reported isoforms (NP_006525.2; NP_858045.1) |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | NCOA3 / SRC-3 / AIB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCOA3 |
|---|---|
| Synonyms | AIB1, BHLHE42, RAC3, TRAM1 |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Cellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus |
| Tissue Location | Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
References
Takeshita A.,et al.J. Biol. Chem. 272:27629-27634(1997).
Chen H.,et al.Cell 90:569-580(1997).
Anzick S.L.,et al.Science 277:965-968(1997).
Li H.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8479-8484(1997).
Deloukas P.,et al.Nature 414:865-871(2001).
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