|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5 µg/ml),|
|Other Names||Akirin-2, AKIRIN2, C6orf166|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||AKIRIN2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).|
|Tissue Location||Widely expressed with the highest expression in peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
Goto A.,et al.Nat. Immunol. 9:97-104(2008).
Goto A.,et al.Nat. Immunol. 9:216-216(2008).
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