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PPP1R12A / MYPT1 Antibody

Goat Polyclonal Antibody

     
  • IHC - PPP1R12A / MYPT1 Antibody ALS12990
    Anti-PPP1R12A / MYPT1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O14974
Reactivity Human, Mouse, Rat, Monkey, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 115kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 4659
Other Names Protein phosphatase 1 regulatory subunit 12A, Myosin phosphatase-targeting subunit 1, Myosin phosphatase target subunit 1, Protein phosphatase myosin-binding subunit, PPP1R12A, MBS, MYPT1
Target/Specificity Human PPP1R12A / MYPT1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPPP1R12A / MYPT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R12A
Synonyms MBS, MYPT1
Function Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.
Cellular Location Cytoplasm. Note=Along actomyosin filaments and stress fibers
Tissue Location Expressed in striated muscles, specifically in type 2a fibers (at protein level).
Research Areas
Citations (0)

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Background

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.

References

Takahashi N.,et al.Genomics 44:150-152(1997).
Guo J.H.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Xia D.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS12990
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