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ANK3 / ANKYRIN-G Antibody

Goat Polyclonal Antibody

     
  • IHC - ANK3 / ANKYRIN-G Antibody ALS12995
    Anti-ANK3 antibody IHC of human brain, cerebellum.
    detail
  • IHC - ANK3 / ANKYRIN-G Antibody ALS12995
    Anti-ANK3 antibody IHC of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q12955
Reactivity Human, Monkey, Pig
Host Goat
Clonality Polyclonal
Calculated MW 480kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 288
Other Names Ankyrin-3, ANK-3, Ankyrin-G, ANK3
Target/Specificity Human ANK3. This antibody is expected to recognise both reported isoforms (NP_001140.2; NP_066267.2)
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsANK3 / ANKYRIN-G Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANK3 (HGNC:494)
Function In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, axon {ECO:0000250|UniProtKB:O70511}. Cell membrane, sarcolemma. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O70511}. Lysosome {ECO:0000250|UniProtKB:G5E8K5}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70511}. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511}
Tissue Location Expressed in brain, neurons, muscles and other tissues.
Research Areas
Citations (0)
citation

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Background

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).

References

Kordeli E.,et al.J. Biol. Chem. 270:2352-2359(1995).
Devarajan P.,et al.J. Cell Biol. 133:819-830(1996).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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Discontinued
Cat# ALS12995
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