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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ANK3 / ANKYRIN-G Antibody   

ANK3 / ANKYRIN-G Antibody

Goat Polyclonal Antibody

     
  • IHC - ANK3 / ANKYRIN-G Antibody ALS12995
    Anti-ANK3 antibody IHC of human brain, cerebellum.
  • IHC - ANK3 / ANKYRIN-G Antibody ALS12995
    Anti-ANK3 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q12955
Reactivity Human, Monkey, Pig
Host Goat
Clonality Polyclonal
Calculated MW 480kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 288
Other Names Ankyrin-3, ANK-3, Ankyrin-G, ANK3
Target/Specificity Human ANK3. This antibody is expected to recognise both reported isoforms (NP_001140.2; NP_066267.2)
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsANK3 / ANKYRIN-G Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANK3
Function In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes
Tissue Location Expressed in brain, neurons, muscles and other tissues.
Research Areas
Citations (0)

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Background

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).

References

Kordeli E.,et al.J. Biol. Chem. 270:2352-2359(1995).
Devarajan P.,et al.J. Cell Biol. 133:819-830(1996).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS12995
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