|Application ||WB, IHC-P, ICC, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ICC (2.5 µg/ml), IHC-P (5 µg/ml), WB (0.5-1 µg/ml)|
|Other Names||E3 ubiquitin-protein ligase MARCH8, 6.3.2.-, Cellular modulator of immune recognition, c-MIR, Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MARCH-VIII, RING finger protein 178, MARCH8, MIR, RNF178|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||MARCH8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein|
|Tissue Location||Broadly expressed. Present in immature dendritic cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Goto E.,et al.J. Biol. Chem. 278:14657-14668(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bartee E.,et al.J. Virol. 78:1109-1120(2004).
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