|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Nucleoporin GLE1, hGLE1, GLE1-like protein, GLE1, GLE1L|
|Target/Specificity||At least three isoforms of Gle1 are known to exist.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||GLE1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658)|
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Provided below are standard protocols that you may find useful for product applications.
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Watkins J.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:6779-6784(1998).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kendirgi F.,et al.J. Cell Biol. 160:1029-1040(2003).
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