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JPH3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - JPH3 Antibody (C-Terminus) ALS13024
    Immunofluorescence of JPH3 in Human Brain cells with JPH3 antibody at 20 ug/ml.
  • WB - JPH3 Antibody (C-Terminus) ALS13024
    Western blot of JPH3 in Daudi cell lysate with JPH3 antibody at 1 ug/ml in (A) the absence and...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WXH2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 57338
Other Names Junctophilin-3, JP-3, Junctophilin type 3, Trinucleotide repeat-containing gene 22 protein, JPH3, JP3, TNRC22
Target/Specificity At least two isoforms of JPH3 are known to exist.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsJPH3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JPH3
Synonyms JP3, TNRC22
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Cellular Location Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity).
Tissue Location Specifically expressed in brain.
Research Areas
Citations (0)

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Background

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory.

References

Nishi M.,et al.Biochem. Biophys. Res. Commun. 273:920-927(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Holmes S.E.,et al.Nat. Genet. 29:377-378(2001).
Stevanin G.,et al.Neurology 58:965-967(2002).
Walker R.H.,et al.Neurology 61:1002-1004(2003).

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$ 395.00
Cat# ALS13024
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