JPH3 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q8WXH2 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 81kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 57338 |
---|---|
Other Names | Junctophilin-3, JP-3, Junctophilin type 3, Trinucleotide repeat-containing gene 22 protein, JPH3, JP3, TNRC22 |
Target/Specificity | At least two isoforms of JPH3 are known to exist. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | JPH3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | JPH3 |
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Synonyms | JP3, TNRC22 |
Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
Cellular Location | Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). |
Tissue Location | Specifically expressed in brain. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory.
References
Nishi M.,et al.Biochem. Biophys. Res. Commun. 273:920-927(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Holmes S.E.,et al.Nat. Genet. 29:377-378(2001).
Stevanin G.,et al.Neurology 58:965-967(2002).
Walker R.H.,et al.Neurology 61:1002-1004(2003).
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