|Application ||IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (1:200-1:400),|
|Other Names||CD166 antigen, Activated leukocyte cell adhesion molecule, CD166, ALCAM, MEMD|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ALCAM / CD166 Antibody (clone 10F1G12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
Bowen M.A.,et al.J. Exp. Med. 181:2213-2220(1995).
Ikeda K.,et al.J. Biol. Chem. 279:55315-55323(2004).
Abe Y.,et al.Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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