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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   CANX / Calnexin Antibody (clone 3H4A7)   

CANX / Calnexin Antibody (clone 3H4A7)

Mouse Monoclonal Antibody

     
  • IF - CANX / Calnexin Antibody (clone 3H4A7) ALS13033
    Confocal immunofluorescence of HeLa cells using Calnexin mouse monoclonal antibody (green).
  • IHC - CANX / Calnexin Antibody (clone 3H4A7) ALS13033
    Anti-Calnexin antibody IHC of human prostate.
  • IHC - CANX / Calnexin Antibody (clone 3H4A7) ALS13033
    Anti-Calnexin antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P27824
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine
Host Mouse
Clonality Monoclonal
Clone Names 3H4A7
Calculated MW 68kDa
Dilution ELISA (1:10000), IF (1:200-1:1000), IHC-P (1:200-1:400), WB (1:500-1:2000) ,
Additional Information
Gene ID 821
Other Names Calnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90, CANX
Target/Specificity Human CANX
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCANX / Calnexin Antibody (clone 3H4A7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CANX
Function Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.

References

David V.,et al.J. Biol. Chem. 268:9585-9592(1993).
Tjoelker L.W.,et al.Biochemistry 33:3229-3236(1994).
Honore B.,et al.Electrophoresis 15:482-490(1994).
Hansen J.J.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS13033
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