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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5)   

EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5)

Mouse Monoclonal Antibody

     
  • IF - EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5) ALS13051
    Confocal immunofluorescence of methanol-fixed HEK293 cells transfected with EphB4-hIgGFc using...
  • IHC - EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5) ALS13051
    Anti-EPHB4 antibody IHC of human brain, cerebellum.
  • IHC - EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5) ALS13051
    Anti-EPHB4 antibody IHC of human colon.
  • IHC - EPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5) ALS13051
    Anti-EPHB4 antibody IHC of human placenta.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P54760
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5B5
Calculated MW 108kDa
Dilution ELISA (1:10000), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) ,
Additional Information
Gene ID 2050
Other Names Ephrin type-B receptor 4, 2.7.10.1, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, EPHB4, HTK, MYK1, TYRO11
Target/Specificity Human EPHB4
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsEPHB4 / EPH Receptor B4 Antibody (Extracellular, clone 5B5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHB4
Synonyms HTK, MYK1, TYRO11
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

References

Bennett B.D.,et al.J. Biol. Chem. 269:14211-14218(1994).
Wilson M.D.,et al.Nucleic Acids Res. 29:1352-1365(2001).
Jin P.,et al.Arthritis Res. Ther. 10:R73-R73(2008).
Fueller T.,et al.J. Cell Sci. 116:2461-2470(2003).
Erber R.,et al.EMBO J. 25:628-641(2006).

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$ 395.00
Cat# ALS13051
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