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BAG3 / BAG-3 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - BAG3 / BAG-3 Antibody (C-Terminus) ALS13069
    Anti-BAG3 antibody IHC of human heart.
  • IHC - BAG3 / BAG-3 Antibody (C-Terminus) ALS13069
    Anti-BAG3 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O95817
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 62kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 9531
Other Names BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG3, BIS
Target/Specificity Human BAG3.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsBAG3 / BAG-3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAG3
Synonyms BIS
Function Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Cellular Location Nucleus. Cytoplasm. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920)
Research Areas
Citations (0)

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Background

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

References

Takayama S.,et al.J. Biol. Chem. 274:781-786(1999).
Lee J.H.,et al.Oncogene 18:6183-6190(1999).
Doong H.,et al.Oncogene 19:4385-4395(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 425.00
Cat# ALS13069
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