|Application ||WB, IHC-P, E|
|Reactivity||Human, Monkey, Pig, Dog|
|Dilution||ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000)|
|Other Names||Thioredoxin reductase 1, cytoplasmic, TR, 220.127.116.11, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF|
|Target/Specificity||Human TXNRD1. This antibody is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1)|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TRXR1 / TXNRD1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.|
|Cellular Location||Cytoplasm. Isoform 5: Cytoplasm.|
|Tissue Location||Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver|
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Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Gasdaska P.Y.,et al.FEBS Lett. 373:5-9(1995).
Koishi R.,et al.J. Biol. Chem. 272:2570-2577(1997).
Hofman E.R.,et al.Mol. Cell. Biol. 18:6493-6504(1998).
Rundloef A.-K.,et al.Free Radic. Biol. Med. 36:641-656(2004).
Schuetze N.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
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