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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SH3BP1 Antibody (C-Terminus)   

SH3BP1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - SH3BP1 Antibody (C-Terminus) ALS13074
    Anti-SH3BP1 antibody IHC of human spleen.
  • IHC - SH3BP1 Antibody (C-Terminus) ALS13074
    Anti-SH3BP1 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y3L3
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 76kDa
Dilution ELISA (1:16000), IHC-P (2.5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 23616
Other Names SH3 domain-binding protein 1, 3BP-1, SH3BP1
Target/Specificity Human SH3BP1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSH3BP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3BP1 (HGNC:10824)
Function GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin- plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).
Cellular Location Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol. Note=Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563) Accumulation at forming phagocytic cups is PI3 kinase/PI3K- dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210).
Research Areas
Citations (0)

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Background

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

References

Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Carrascal M.,et al.J. Proteome Res. 7:5167-5176(2008).

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$ 425.00
Cat# ALS13074
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