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>   home   >   Products   >   Primary Antibodies   >   DDX5 Antibody (C-Terminus)   

DDX5 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - DDX5 Antibody (C-Terminus) ALS13075
    Antibody staining (0.5 ug/ml) of A431 cell lysate (RIPA buffer, 35 ug total protein per lane).
  • IHC - DDX5 Antibody (C-Terminus) ALS13075
    Anti-DDX5 antibody IHC of human breast.
  • IHC - DDX5 Antibody (C-Terminus) ALS13075
    Anti-DDX5 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P17844
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 69kDa
Dilution ELISA (1:64000), IHC-P (2.5 µg/ml), WB (1:64000)
Additional Information
Gene ID 1655
Other Names Probable ATP-dependent RNA helicase DDX5, 3.6.4.13, DEAD box protein 5, RNA helicase p68, DDX5, G17P1, HELR, HLR1
Target/Specificity Human DDX5.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDDX5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDX5
Synonyms G17P1, HELR, HLR1
Function Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Cellular Location Nucleus, nucleolus
Citations (0)

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Background

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

References

Hloch P.,et al.Nucleic Acids Res. 18:3045-3045(1990).
Iggo R.D.,et al.Mol. Cell. Biol. 11:1326-1333(1991).
Roessler O.G.,et al.Nucleic Acids Res. 28:932-939(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS13075
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