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PTCH1 / Patched Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - PTCH1 / Patched Antibody (C-Terminus) ALS13082
    Anti-PTCH1 antibody IHC of human breast.
    detail
  • IHC - PTCH1 / Patched Antibody (C-Terminus) ALS13082
    Anti-PTCH1 antibody IHC of human colon.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q13635
Reactivity Human, Monkey, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 161kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 5727
Other Names Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH
Target/Specificity Human PTCH1. This antibody is expected to recognise all reported isoforms. Variants (NP_001077073.1; NP_001077074.1; NP_001077075.1; NP_001077076.1) encode the same isoform.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPTCH1 / Patched Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTCH1
Synonyms PTCH
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein
Tissue Location In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin
Research Areas
Citations (0)
citation

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Background

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

References

Johnson R.L.,et al.Science 272:1668-1671(1996).
Hahn H.,et al.J. Biol. Chem. 271:12125-12128(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Nagao K.,et al.Genomics 85:462-471(2005).
Shimokawa T.,et al.Oncogene 26:4889-4896(2007).

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Discontinued
Cat# ALS13082
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