|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-1 µg/ml)|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4D, 220.127.116.11, DPDE3, PDE43, PDE4D, DPDE3|
|Target/Specificity||Human PDE4D. This antiobody is expected to recognize all reported isoforms.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||PDE4D Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.|
|Tissue Location||Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Bolger G.,et al.Mol. Cell. Biol. 13:6558-6571(1993).
Nemoz G.,et al.FEBS Lett. 384:97-102(1996).
Baecker P.A.,et al.Gene 138:253-256(1994).
Bolger G.B.,et al.Biochem. J. 328:539-548(1997).
Miro X.,et al.Biochem. Biophys. Res. Commun. 274:415-421(2000).
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