PDE4D Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q08499 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 91kDa |
Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-1 µg/ml) |
Gene ID | 5144 |
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Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4D, 3.1.4.53, DPDE3, PDE43, PDE4D, DPDE3 |
Target/Specificity | Human PDE4D. This antiobody is expected to recognize all reported isoforms. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | PDE4D Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PDE4D (HGNC:8783) |
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Synonyms | DPDE3 |
Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Cellular Location | Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity) Colocalized with SHANK2 to the apical membrane of colonic crypt cells |
Tissue Location | Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle [Isoform 8]: Detected in brain, placenta, lung and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
References
Bolger G.,et al.Mol. Cell. Biol. 13:6558-6571(1993).
Nemoz G.,et al.FEBS Lett. 384:97-102(1996).
Baecker P.A.,et al.Gene 138:253-256(1994).
Bolger G.B.,et al.Biochem. J. 328:539-548(1997).
Miro X.,et al.Biochem. Biophys. Res. Commun. 274:415-421(2000).
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