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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SCD1 / SCD Antibody (C-Terminus)   

SCD1 / SCD Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - SCD1 / SCD Antibody (C-Terminus) ALS13084
    Anti-SCD antibody IHC of human colon.
  • IHC - SCD1 / SCD Antibody (C-Terminus) ALS13084
    Anti-SCD antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O00767
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 42kDa
Dilution ELISA (1:64000), IHC-P (5 µg/ml),
Additional Information
Gene ID 6319
Other Names Acyl-CoA desaturase, 1.14.19.1, Delta(9)-desaturase, Delta-9 desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase, SCD
Target/Specificity Human SCD.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSCD1 / SCD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCD
Function Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:18765284, ECO:0000305}
Tissue Location Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
Research Areas
Citations (0)

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Background

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

References

Al-Jeryan L.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Zhang L.,et al.Biochem. J. 340:255-264(1999).
Hoshino T.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13084
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