|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:8000), IHC-P (5 µg/ml), WB (1:8000)|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, 188.8.131.52, DPDE4, PDE32, PDE4B, DPDE4|
|Target/Specificity||Human PDE4B. This antibody is expected to recognise all reported isoforms (NP_002591.2, NP_001032418.1, NP_001032416.1 and NP_001032417.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||PDE4B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.|
|Tissue Location||Expressed in brain, heart, lung and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Obernolte R.,et al.Gene 129:239-247(1993).
Bolger G.,et al.Mol. Cell. Biol. 13:6558-6571(1993).
Huston E.,et al.Biochem. J. 328:549-558(1997).
McLaughlin M.M.,et al.J. Biol. Chem. 268:6470-6476(1993).
Cheung Y.F.,et al.J. Pharmacol. Exp. Ther. 322:600-609(2007).
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