F2R / Thrombin Receptor / PAR1 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P25116 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Dilution | ELISA (1:3200), IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml) |
Gene ID | 2149 |
---|---|
Other Names | Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR |
Target/Specificity | Human F2R / Thrombin receptor. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | F2R / Thrombin Receptor / PAR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | F2R |
---|---|
Synonyms | CF2R, PAR1, TR |
Function | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Platelets and vascular endothelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
References
Vu T.-K.H.,et al.Cell 64:1057-1068(1991).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shapiro M.J.,et al.J. Biol. Chem. 271:32874-32880(1996).
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
Zania P.,et al.J. Pharmacol. Exp. Ther. 328:378-389(2009).
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