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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   VTCN1 / B7-H4 Antibody (clone H74)   

VTCN1 / B7-H4 Antibody (clone H74)

Mouse Monoclonal Antibody

     
  • IHC - VTCN1 / B7-H4 Antibody (clone H74) ALS13122
    Anti-VTCN1 / B7-H4 antibody IHC of human pancreas.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, Flo
Primary Accession Q7Z7D3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names H74
Calculated MW 31kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 79679
Other Names V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7-H4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Reconstitution & Storage Store at 2-8°C
PrecautionsVTCN1 / B7-H4 Antibody (clone H74) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}
Tissue Location Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Research Areas
Citations (0)

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Background

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

References

Sica G.L.,et al.Immunity 18:849-861(2003).
Zang X.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003).
Sun Y.,et al.Lung Cancer 53:143-151(2006).
Mao Y.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS13122
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