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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARL2 Antibody   

ARL2 Antibody

Rabbit Polyclonal Antibody

     
  • WB - ARL2 Antibody ALS13129
    Sample(30 g of whole cell lysate). A: H1299. 15% SDS PAGE. ARL2 antibody diluted at 1:1000.
  • IHC - ARL2 Antibody ALS13129
    Anti-ARL2 antibody IHC of human breast.
  • IHC - ARL2 Antibody ALS13129
    Anti-ARL2 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P36404
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 402
Other Names ADP-ribosylation factor-like protein 2, ARL2
Target/Specificity Human ARL2.
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsARL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARL2
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
Cellular Location Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle Not detected to interphase microtubules.
Volume 50 µl
Research Areas
Citations (0)

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Background

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

References

Clark J.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8952-8956(1993).
Kahn R.A.,et al.Submitted (NOV-1997) to UniProtKB.
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS13129
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