|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Bovine|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, ADRA1A, ADRA1C|
|Target/Specificity||Human Adrenergic receptor alpha 1a.|
|Reconstitution & Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ADRA1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes|
|Tissue Location||Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart|
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Provided below are standard protocols that you may find useful for product applications.
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Hirasawa A.,et al.Biochem. Biophys. Res. Commun. 195:902-909(1993).
Weinberg D.H.,et al.Biochem. Biophys. Res. Commun. 201:1296-1304(1994).
Forray C.,et al.Mol. Pharmacol. 45:703-708(1994).
Tseng-Crank J.,et al.Br. J. Pharmacol. 115:1475-1485(1995).
Hirasawa A.,et al.FEBS Lett. 363:256-260(1995).
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