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EPHB3 / EPH Receptor B3 Antibody (clone 4A122D1)

Mouse Monoclonal Antibody

     
  • IHC - EPHB3 / EPH Receptor B3 Antibody (clone 4A122D1) ALS13146
    Anti-EPHB3 antibody IHC of human adrenal.
  • IHC - EPHB3 / EPH Receptor B3 Antibody (clone 4A122D1) ALS13146
    Anti-EPHB3 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P54753
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4A122D1
Calculated MW 110kDa
Dilution ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 2049
Other Names Ephrin type-B receptor 3, 2.7.10.1, EPH-like tyrosine kinase 2, EPH-like kinase 2, Embryonic kinase 2, EK2, hEK2, Tyrosine-protein kinase TYRO6, EPHB3, ETK2, HEK2, TYRO6
Target/Specificity Human EPHB3
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsEPHB3 / EPH Receptor B3 Antibody (clone 4A122D1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHB3
Synonyms ETK2, HEK2, TYRO6
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
Cellular Location Cell membrane; Single-pass type I membrane protein Cell projection, dendrite
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

References

Boehme B.,et al.Oncogene 8:2857-2862(1993).
Hock B.,et al.Oncogene 17:255-260(1998).
Miao H.,et al.J. Biol. Chem. 280:923-932(2005).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
Greenman C.,et al.Nature 446:153-158(2007).

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$ 395.00
Cat# ALS13146
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