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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   EPHA7 / EPH Receptor A6 Antibody (clone 6C8G7)   

EPHA7 / EPH Receptor A6 Antibody (clone 6C8G7)

Mouse Monoclonal Antibody

     
  • IHC - EPHA7 / EPH Receptor A6 Antibody (clone 6C8G7) ALS13153
    Anti-EPHA7 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q15375
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6C8G7
Calculated MW 112kDa
Dilution ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 2045
Other Names Ephrin type-A receptor 7, 2.7.10.1, EPH homology kinase 3, EHK-3, EPH-like kinase 11, EK11, hEK11, EPHA7, EHK3, HEK11
Target/Specificity Human EPHA7
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsEPHA7 / EPH Receptor A6 Antibody (clone 6C8G7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHA7
Synonyms EHK3, HEK11
Function Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

References

Fox G.M.,et al.Oncogene 10:897-905(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13153
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