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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BHMT Antibody (clone 8C11H5)   

BHMT Antibody (clone 8C11H5)

Mouse Monoclonal Antibody

     
  • IHC - BHMT Antibody (clone 8C11H5) ALS13155
    Anti-BHMT antibody IHC of human kidney.
  • IHC - BHMT Antibody (clone 8C11H5) ALS13155
    Anti-BHMT antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q93088
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8C11H5
Calculated MW 45kDa
Dilution IHC-P (1:200), WB (1:500-1:2000),
Additional Information
Other Names Betaine--homocysteine S-methyltransferase 1, 2.1.1.5, BHMT
Target/Specificity Human BHMT
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsBHMT Antibody (clone 8C11H5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BHMT
Function Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
Cellular Location Cytoplasm.
Tissue Location Found exclusively in liver and kidney. EMBL; U50929; AAC50668.1; -; mRNA EMBL; AF118378; AAD22043.1; -; Genomic_DNA EMBL; AF118371; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118372; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118373; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118374; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118375; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118376; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118377; AAD22043.1; JOINED; Genomic_DNA EMBL; BC012616; AAH12616.1; -; mRNA CCDS; CCDS4046.1; - RefSeq; NP_001704.2; NM_001713.2 UniGene; Hs.80756; - PDB; 1LT7; X-ray; 2.15 A; A/B=1-406 PDB; 1LT8; X-ray; 2.05 A; A/B=1-406 PDB; 4M3P; X-ray; 1.90 A; A/B/C/D=1-406 PDBsum; 1LT7; - PDBsum; 1LT8; - PDBsum; 4M3P; - ProteinModelPortal; Q93088; - SMR; Q93088; - BioGrid; 107104; 11 IntAct; Q93088; 6 MINT; Q93088; - STRING; 9606.ENSP00000274353; - BindingDB; Q93088; - ChEMBL; CHEMBL4328; - DrugBank; DB04272; Citric Acid DrugBank; DB00134; L-Methionine DrugBank; DB02337; S-(D-Carboxybutyl)-L-Homocysteine iPTMnet; Q93088; - PhosphoSitePlus; Q93088; - BioMuta; BHMT; - DMDM; 145559446; - EPD; Q93088; - PaxDb; Q93088; - PeptideAtlas; Q93088; - PRIDE; Q93088; - ProteomicsDB; 75719; - Ensembl; ENST00000274353; ENSP00000274353; ENSG00000145692 GeneID; 635; - KEGG; hsa:635; - CTD; 635; - DisGeNET; 635; - EuPathDB; HostDB:ENSG00000145692.14; - GeneCards; BHMT; - HGNC; HGNC:1047; BHMT HPA; HPA038285; - HPA; HPA058310; - MIM; 602888; gene neXtProt; NX_Q93088; - OpenTargets; ENSG00000145692; - PharmGKB; PA25350; - eggNOG; KOG1579; Eukaryota eggNOG; COG0646; LUCA GeneTree; ENSGT00390000003122; - HOGENOM; HOG000231636; - HOVERGEN; HBG080367; - InParanoid; Q93088; - KO; K00544; - OMA; PYCPSMS; - OrthoDB; EOG091G09QD; - PhylomeDB; Q93088; - TreeFam; TF329202; - BioCyc; MetaCyc:HS07273-MONOMER; - BRENDA; 2.1.1.5; 2681 Reactome; R-HSA-1614635; Sulfur amino acid metabolism Reactome; R-HSA-6798163; Choline catabolism SABIO-RK; Q93088; - SIGNOR; Q93088; - UniPathway; UPA00051; UER00083 UniPathway; UPA00291; UER00432 ChiTaRS; BHMT; human EvolutionaryTrace; Q93088; - GenomeRNAi; 635; - PRO; PR:Q93088; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000145692; - CleanEx; HS_BHMT; - ExpressionAtlas; Q93088; baseline and differential Genevisible; Q93088; HS GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IDA:BHF-UCL GO; GO:0008270; F:zinc ion binding; IDA:BHF-UCL GO; GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway GO; GO:0006577; P:amino-acid betaine metabolic process; IDA:BHF-UCL GO; GO:0042426; P:choline catabolic process; TAS:Reactome GO; GO:0071267; P:L-methionine salvage; IDA:BHF-UCL GO; GO:0006479; P:protein methylation; NAS:UniProtKB GO; GO:0050666; P:regulation of homocysteine metabolic process; NAS:UniProtKB GO; GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome Gene3D; 3.20.20.330; -; 1 InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT InterPro; IPR003726; HCY_dom InterPro; IPR036589; HCY_dom_sf Pfam; PF02574; S-methyl_trans; 1 PIRSF; PIRSF037505; Betaine_HMT; 1 SUPFAM; SSF82282; SSF82282; 1 PROSITE; PS50970; HCY; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Zinc CHAIN 1 406 Betaine--homocysteine S-methyltransferase 1 /FTId=PRO_0000114621 DOMAIN 11 314 Hcy-binding. {ECO:0000255|PROSITE- ProRule:PRU00333} METAL 217 217 Zinc METAL 299 299 Zinc METAL 300 300 Zinc MOD_RES 40 40 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 93 93 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 232 232 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 241 241 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 330 330 Phosphoserine {ECO:0000250|UniProtKB:O09171} MOD_RES 340 340 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 377 377 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} VARIANT 199 199 G -> S (in dbSNP:rs59866108) /FTId=VAR_061345 VARIANT 239 239 R -> Q (may decrease risk for coronary artery disease; dbSNP:rs3733890) /FTId=VAR_015886 HELIX 13 18 {ECO:0000244|PDB:4M3P} HELIX 29 35 {ECO:0000244|PDB:4M3P} TURN 41 43 {ECO:0000244|PDB:4M3P} HELIX 48 51 {ECO:0000244|PDB:4M3P} HELIX 53 66 {ECO:0000244|PDB:4M3P} STRAND 69 72 {ECO:0000244|PDB:4M3P} HELIX 97 111 {ECO:0000244|PDB:4M3P} TURN 112 115 {ECO:0000244|PDB:4M3P} STRAND 117 123 {ECO:0000244|PDB:4M3P} HELIX 126 129 {ECO:0000244|PDB:1LT8} HELIX 134 151 {ECO:0000244|PDB:4M3P} STRAND 154 162 {ECO:0000244|PDB:4M3P} HELIX 164 175 {ECO:0000244|PDB:4M3P} STRAND 181 185 {ECO:0000244|PDB:4M3P} HELIX 198 207 {ECO:0000244|PDB:4M3P} STRAND 211 219 {ECO:0000244|PDB:4M3P} HELIX 221 237 {ECO:0000244|PDB:4M3P} STRAND 243 247 {ECO:0000244|PDB:4M3P} HELIX 261 263 {ECO:0000244|PDB:4M3P} TURN 265 269 {ECO:0000244|PDB:4M3P} HELIX 272 274 {ECO:0000244|PDB:4M3P} HELIX 278 290 {ECO:0000244|PDB:4M3P} STRAND 293 296 {ECO:0000244|PDB:4M3P} HELIX 304 313 {ECO:0000244|PDB:4M3P} HELIX 315 318 {ECO:0000244|PDB:4M3P} HELIX 323 327 {ECO:0000244|PDB:4M3P} HELIX 330 335 {ECO:0000244|PDB:4M3P} HELIX 341 344 {ECO:0000244|PDB:4M3P} HELIX 349 354 {ECO:0000244|PDB:4M3P} HELIX 377 400 {ECO:0000244|PDB:4M3P} SEQUENCE 406 AA; 44998 MW; 557855B8CEDD0D54 CRC64; MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

References

Garrow T.A.,et al.J. Biol. Chem. 271:22831-22838(1996).
Park E.I.,et al.J. Biol. Chem. 274:7816-7824(1999).
Sunden S.L.F.,et al.Arch. Biochem. Biophys. 345:171-174(1997).
Millian N.S.,et al.Arch. Biochem. Biophys. 356:93-98(1998).
Evans J.C.,et al.Structure 10:1159-1171(2002).

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$ 425.00
Cat# ALS13155
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