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BHMT Antibody (clone 8C11H5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q93088 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8C11H5 |
| Calculated MW | 45kDa |
| Dilution | IHC-P (1:200), WB (1:500-1:2000), |
| Gene ID | 635 |
|---|---|
| Other Names | Betaine--homocysteine S-methyltransferase 1, 2.1.1.5, BHMT |
| Target/Specificity | Human BHMT |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | BHMT Antibody (clone 8C11H5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BHMT {ECO:0000303|PubMed:8798461} |
|---|---|
| Function | Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171} Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171} |
| Tissue Location | Found exclusively in liver and kidney. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
References
Garrow T.A.,et al.J. Biol. Chem. 271:22831-22838(1996).
Park E.I.,et al.J. Biol. Chem. 274:7816-7824(1999).
Sunden S.L.F.,et al.Arch. Biochem. Biophys. 345:171-174(1997).
Millian N.S.,et al.Arch. Biochem. Biophys. 356:93-98(1998).
Evans J.C.,et al.Structure 10:1159-1171(2002).
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