CD80 Antibody (clone 2A2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IF, E |
---|---|
Primary Accession | P33681 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2A2 |
Calculated MW | 33kDa |
Dilution | IF (1:200-1:1000), IHC-P (1:200), |
Gene ID | 941 |
---|---|
Other Names | T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD80, CD80, CD28LG, CD28LG1, LAB7 |
Target/Specificity | Human CD80 |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | CD80 Antibody (clone 2A2) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD80 |
---|---|
Synonyms | CD28LG, CD28LG1, LAB7 |
Function | Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed on activated B-cells, macrophages and dendritic cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
References
Freeman G.J.,et al.J. Immunol. 143:2714-2722(1989).
Selvakumar A.,et al.Immunogenetics 36:175-181(1992).
Kakoulidou M.,et al.Scand. J. Immunol. 66:529-537(2007).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Freeman G.J.,et al.J. Exp. Med. 174:625-631(1991).
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