MTHFD1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P11586 |
Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 102kDa |
Dilution | ELISA (1:1000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Gene ID | 4522 |
---|---|
Other Names | C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase, Methylenetetrahydrofolate dehydrogenase, 1.5.1.5, Methenyltetrahydrofolate cyclohydrolase, 3.5.4.9, Formyltetrahydrofolate synthetase, 6.3.4.3, C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed, MTHFD1, MTHFC, MTHFD |
Target/Specificity | Human MTHFD1. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | MTHFD1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MTHFD1 |
---|---|
Synonyms | MTHFC, MTHFD |
Function | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:1881876, PubMed:10828945, PubMed:18767138). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:25633902, PubMed:18767138). |
Cellular Location | Cytoplasm. |
Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Hum D.W.,et al.J. Biol. Chem. 263:15946-15950(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.