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RTN3 / Reticulon 3 Antibody (clone 10A8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O95197 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10A8 |
| Calculated MW | 113kDa |
| Dilution | ELISA (1:10000), IHC-P (1:200), |
| Gene ID | 10313 |
|---|---|
| Other Names | Reticulon-3, Homolog of ASY protein, HAP, Neuroendocrine-specific protein-like 2, NSP-like protein 2, Neuroendocrine-specific protein-like II, NSP-like protein II, NSPLII, RTN3, ASYIP, NSPL2 |
| Target/Specificity | Human RTN3 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RTN3 / Reticulon 3 Antibody (clone 10A8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTN3 |
|---|---|
| Synonyms | ASYIP, NSPL2 |
| Function | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.
References
Moreira E.F.,et al.Genomics 58:73-81(1999).
Qi B.,et al.J. Cell. Physiol. 196:312-318(2003).
Huang X.,et al.Clin. Neuropathol. 23:1-7(2004).
Cai Y.,et al.Brain Res. Mol. Brain Res. 138:236-243(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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