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WNT1 Antibody (clone 10C8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, FC |
|---|---|
| Primary Accession | P04628 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10C8 |
| Calculated MW | 41kDa |
| Dilution | ELISA (1:10000), Flo (1:200-1:400), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) |
| Gene ID | 7471 |
|---|---|
| Other Names | Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog, WNT1, INT1 |
| Target/Specificity | Human WNT1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | WNT1 Antibody (clone 10C8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WNT1 |
|---|---|
| Synonyms | INT1 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.
References
van Ooyen A.,et al.EMBO J. 4:2905-2909(1985).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Doubravska L.,et al.Cell. Signal. 23:837-848(2011).
Keupp K.,et al.Am. J. Hum. Genet. 92:565-574(2013).
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