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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MTDH / Metadherin Antibody (clone 2F11C3)   

MTDH / Metadherin Antibody (clone 2F11C3)

Mouse Monoclonal Antibody

     
  • IHC - MTDH / Metadherin Antibody (clone 2F11C3) ALS13172
    Anti-MTDH antibody IHC of human prostate.
  • IHC - MTDH / Metadherin Antibody (clone 2F11C3) ALS13172
    Anti-MTDH antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Flo
Primary Accession Q86UE4
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F11C3
Calculated MW 64kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), IHC-P (1:200), WB (1:500-1:2000) ,
Additional Information
Gene ID 92140
Other Names Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, AEG-1, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein, MTDH, AEG1, LYRIC
Target/Specificity Human MTDH
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMTDH / Metadherin Antibody (clone 2F11C3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTDH
Synonyms AEG1, LYRIC
Function Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
Tissue Location Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme
Research Areas
Citations (0)

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Background

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

References

Sutherland H.G.E.,et al.Exp. Cell Res. 294:94-105(2004).
Britt D.E.,et al.Exp. Cell Res. 300:134-148(2004).
Kang D.-C.,et al.Gene 353:8-15(2005).
Liang Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS13172
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