|Application ||WB, IHC-P, E, Flo|
|Dilution||Flo (1:200-1:400), IHC-P (1:200), WB (1:500-1:2000)|
|Other Names||Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Argraves W.S.,et al.J. Cell Biol. 105:1183-1190(1987).
Birkenmeier T.M.,et al.J. Biol. Chem. 266:20544-20549(1991).
Fitzgerald L.A.,et al.Biochemistry 26:8158-8165(1987).
Argraves W.S.,et al.J. Biol. Chem. 261:12922-12924(1986).
Takada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987).
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