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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6)   

ITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6)

Mouse Monoclonal Antibody

     
  • IHC - ITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6) ALS13175
    Anti-ITGA5 / Integrin Alpha 5 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Flo
Primary Accession P08648
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10F6
Calculated MW 115kDa
Dilution Flo (1:200-1:400), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 3678
Other Names Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA
Target/Specificity Human ITGA5
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA5
Synonyms FNRA
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
Cellular Location Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface
Research Areas
Citations (0)

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Background

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

References

Argraves W.S.,et al.J. Cell Biol. 105:1183-1190(1987).
Birkenmeier T.M.,et al.J. Biol. Chem. 266:20544-20549(1991).
Fitzgerald L.A.,et al.Biochemistry 26:8158-8165(1987).
Argraves W.S.,et al.J. Biol. Chem. 261:12922-12924(1986).
Takada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987).

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$ 395.00
Cat# ALS13175
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