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AR / Androgen Receptor Antibody (clone 2H8)

Mouse Monoclonal Antibody

     
  • IHC - AR / Androgen Receptor Antibody (clone 2H8) ALS13184
    Anti-Androgen Receptor antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P10275
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H8
Calculated MW 99kDa
Dilution ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 367
Other Names Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Target/Specificity Human AR
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAR / Androgen Receptor Antibody (clone 2H8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1
Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle.
Research Areas
Citations (0)

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Background

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

References

Lubahn D.B.,et al.Mol. Endocrinol. 2:1265-1275(1988).
Chang C.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7211-7215(1988).
Tilley W.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:327-331(1989).
Lubahn D.B.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9534-9538(1989).
Govindan M.V.,et al.Mol. Endocrinol. 4:417-427(1990).

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$ 395.00
Cat# ALS13184
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