|Dilution||IHC-P (3.75 µg/ml)|
|Other Names||Cytochrome P450 26A1, 1.14.-.-, Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, CYP26A1, CYP26, P450RAI1|
|Target/Specificity||Human CYP26A1. This antibody is expected to recognize both reported isoforms (NP_000774.2; NP_476498.1)|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CYP26 / CYP26A1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain|
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Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
White J.A.,et al.J. Biol. Chem. 272:18538-18541(1997).
Sonneveld E.,et al.Cell Growth Differ. 9:629-637(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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