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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP26 / CYP26A1 Antibody (Internal)   

CYP26 / CYP26A1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - CYP26 / CYP26A1 Antibody (Internal) ALS13190
    Anti-CYP26A1 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O43174
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 56kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 1592
Other Names Cytochrome P450 26A1, 1.14.-.-, Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, CYP26A1, CYP26, P450RAI1
Target/Specificity Human CYP26A1. This antibody is expected to recognize both reported isoforms (NP_000774.2; NP_476498.1)
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCYP26 / CYP26A1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP26A1
Synonyms CYP26, P450RAI1
Function Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Tissue Location Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain
Research Areas
Citations (0)

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Background

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

References

White J.A.,et al.J. Biol. Chem. 272:18538-18541(1997).
Sonneveld E.,et al.Cell Growth Differ. 9:629-637(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13190
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