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>   home   >   Products   >   Primary Antibodies   >   NKX3-1 Antibody (clone 4H4)   

NKX3-1 Antibody (clone 4H4)

Mouse Monoclonal Antibody

     
  • IHC - NKX3-1 Antibody (clone 4H4) ALS13202
    Anti-NKX3-1 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Flo
Primary Accession Q99801
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4H4
Calculated MW 26kDa
Dilution Flo (1:200-1:400), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 4824
Other Names Homeobox protein Nkx-3.1, Homeobox protein NK-3 homolog A, NKX3-1, NKX3.1, NKX3A
Target/Specificity Human NKX3-1
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsNKX3-1 Antibody (clone 4H4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX3-1
Synonyms NKX3.1, NKX3A
Function Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:11137288}
Tissue Location Highly expressed in the prostate and, at a lower level, in the testis.
Volume 50 µl
Citations (0)

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Background

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

References

He W.-W.,et al.Genomics 43:69-77(1997).
Prescott J.L.,et al.Prostate 35:71-80(1998).
Korkmaz K.S.,et al.Gene 260:25-36(2000).
Chen H.,et al.Cancer Res. 62:338-340(2002).
Hosohata K.,et al.Mol. Cell. Biol. 23:7019-7029(2003).

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$ 395.00
Cat# ALS13202
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