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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CDH2 / N Cadherin Antibody (clone 5D5)   

CDH2 / N Cadherin Antibody (clone 5D5)

Mouse Monoclonal Antibody

     
  • IF - CDH2 / N Cadherin Antibody (clone 5D5) ALS13206
    Immunofluorescence of A431 cells using CDH2 mouse monoclonal antibody (green).
  • IHC - CDH2 / N Cadherin Antibody (clone 5D5) ALS13206
    Anti-CDH2 / N Cadherin antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P19022
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 5D5
Calculated MW 100kDa
Dilution IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 1000
Other Names Cadherin-2, CDw325, Neural cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD
Target/Specificity Human CDH2
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCDH2 / N Cadherin Antibody (clone 5D5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDH2
Synonyms CDHN, NCAD
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Volume 50 µl
Research Areas
Citations (0)

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Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

References

Reid R.A.,et al.Nucleic Acids Res. 18:5896-5896(1990).
Reid R.A.,et al.Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
Salomon D.,et al.J. Cell Sci. 102:7-17(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).

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$ 395.00
Cat# ALS13206
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