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MUM1 Antibody (clone 4G10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q2TAK8 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4G10 |
| Calculated MW | 79kDa |
| Dilution | IHC-P (1:200), WB (1:500-1:2000), |
| Gene ID | 84939 |
|---|---|
| Other Names | PWWP domain-containing protein MUM1, Mutated melanoma-associated antigen 1, MUM-1, Protein expandere, MUM1, EXPAND1 |
| Target/Specificity | Human MUM1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MUM1 Antibody (clone 4G10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PWWP3A (HGNC:29641) |
|---|---|
| Function | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. |
| Cellular Location | Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1 |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
References
Grimwood J.,et al.Nature 428:529-535(2004).
Coulie P.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7976-7980(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Huen M.S.,et al.Mol. Cell 37:854-864(2010).
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