|Application ||WB, IHC-P, E|
|Dilution||IHC-P (1:200), WB (1:500-1:2000),|
|Other Names||PWWP domain-containing protein MUM1, Mutated melanoma-associated antigen 1, MUM-1, Protein expandere, MUM1, EXPAND1|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MUM1 Antibody (clone 4G10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.|
|Cellular Location||Nucleus. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Grimwood J.,et al.Nature 428:529-535(2004).
Coulie P.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7976-7980(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Huen M.S.,et al.Mol. Cell 37:854-864(2010).
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