|Reactivity||Human, Mouse, Monkey|
|Dilution||IHC-P (3.75 µg/ml)|
|Other Names||3-oxo-5-alpha-steroid 4-dehydrogenase 1, 18.104.22.168, SR type 1, Steroid 5-alpha-reductase 1, S5AR 1, SRD5A1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||5-Alpha Reductase / SRD5A1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|
|Cellular Location||Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Liver and prostate (at a low level).|
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Provided below are standard protocols that you may find useful for product applications.
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Andersson S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990).
Jenkins E.P.,et al.Genomics 11:1102-1112(1991).
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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