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PDGF-BB Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P01127 |
| Reactivity | Human, Sheep, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 27kDa |
| Dilution | IHC-P (3.75 µg/ml) |
| Gene ID | 5155 |
|---|---|
| Other Names | Platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin, PDGFB, PDGF2, SIS |
| Target/Specificity | Human PDGFB. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | PDGF-BB Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDGFB |
|---|---|
| Synonyms | PDGF2, SIS |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). |
| Cellular Location | Secreted. Note=Released by platelets upon wounding |
| Tissue Location | Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
References
Josephs S.F.,et al.Science 225:636-639(1984).
Collins T.,et al.Nature 316:748-750(1985).
Ratner L.,et al.Nucleic Acids Res. 13:5007-5018(1985).
Rao C.D.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:959-966(1986).
Rao C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2392-2396(1986).
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