|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Inactive heparanase-2, Hpa2, HPSE2, HPA2|
|Target/Specificity||Human and mouse HPSE2. Predicted cross-reactivity based on amino acid sequence homology: mouse (100%), rat (99%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||Heparanase 2 / HPSE2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
McKenzie E.,et al.Biochem. Biophys. Res. Commun. 276:1170-1177(2000).
Legoux P.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Pang J.,et al.Am. J. Hum. Genet. 86:957-962(2010).
Pang J.,et al.Am. J. Hum. Genet. 87:161-161(2010).
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