|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Inactive heparanase-2, Hpa2, HPSE2, HPA2|
|Target/Specificity||Human and mouse HPSE2. Predicted cross-reactivity based on amino acid sequence homology: mouse (100%), rat (99%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||Heparanase 2 / HPSE2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
McKenzie E.,et al.Biochem. Biophys. Res. Commun. 276:1170-1177(2000).
Legoux P.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Pang J.,et al.Am. J. Hum. Genet. 86:957-962(2010).
Pang J.,et al.Am. J. Hum. Genet. 87:161-161(2010).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.