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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Heparanase 2 / HPSE2 Antibody   

Heparanase 2 / HPSE2 Antibody

Rabbit Polyclonal Antibody

     
  • WB - Heparanase 2 / HPSE2 Antibody ALS13230
    Sample(30 ug whole cell lysate).
  • WB - Heparanase 2 / HPSE2 Antibody ALS13230
    Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. HPSE2 antibody diluted at 1:1000.
  • IHC - Heparanase 2 / HPSE2 Antibody ALS13230
    Anti-HPSE2 antibody IHC of human prostate.
  • IHC - Heparanase 2 / HPSE2 Antibody ALS13230
    Anti-HPSE2 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8WWQ2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 67kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 60495
Other Names Inactive heparanase-2, Hpa2, HPSE2, HPA2
Target/Specificity Human and mouse HPSE2. Predicted cross-reactivity based on amino acid sequence homology: mouse (100%), rat (99%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsHeparanase 2 / HPSE2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPSE2
Synonyms HPA2
Function Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

References

McKenzie E.,et al.Biochem. Biophys. Res. Commun. 276:1170-1177(2000).
Legoux P.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Pang J.,et al.Am. J. Hum. Genet. 86:957-962(2010).
Pang J.,et al.Am. J. Hum. Genet. 87:161-161(2010).

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$ 395.00
Cat# ALS13230
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