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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ADAM15 Antibody   

ADAM15 Antibody

Rabbit Polyclonal Antibody

     
  • WB - ADAM15 Antibody ALS13240
    Sample (30 ug of whole cell lysate). A: Hep G2. 7.5% SDS PAGE. ADAM15 antibody diluted at 1:1000.
  • WB - ADAM15 Antibody ALS13240
    Sample (30 ug of whole cell lysate).
  • IHC - ADAM15 Antibody ALS13240
    Anti-ADAM15 antibody IHC of human placenta.
  • IHC - ADAM15 Antibody ALS13240
    Anti-ADAM15 antibody IHC of human thyroid.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q13444
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 93kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 8751
Other Names Disintegrin and metalloproteinase domain-containing protein 15, ADAM 15, 3.4.24.-, Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, MDC-15, Metargidin, ADAM15, MDC15
Target/Specificity Human and mouse ADAM15.
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsADAM15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAM15
Synonyms MDC15
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Cellular Location Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity).
Tissue Location Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes Expressed in airway smooth muscle and glomerular mesangial cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

References

Kraetzschmar J.,et al.J. Biol. Chem. 271:4593-4596(1996).
Herren B.,et al.FASEB J. 11:173-180(1997).
Charrier L.,et al.Am. J. Physiol. 288:G346-G353(2005).
Kleino I.,et al.BMC Mol. Biol. 8:90-90(2007).
Zhong J.L.,et al.Mol. Cancer Res. 6:383-394(2008).

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$ 395.00
Cat# ALS13240
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