|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Actin-related protein 2, Actin-like protein 2, ACTR2, ARP2|
|Target/Specificity||Human Arp2. Predicted cross-reactivity based on amino acid sequence homology: rat (99%), zebrafish (86%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||ACTR2 / ARP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection|
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Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.
Welch M.D.,et al.J. Cell Biol. 138:375-384(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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