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F12 / Factor XII Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P00748 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Calculated MW | 68kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 2161 |
|---|---|
| Other Names | Coagulation factor XII, 3.4.21.38, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12 |
| Target/Specificity | Recognises Factor XII |
| Reconstitution & Storage | Store at -70°C. |
| Precautions | F12 / Factor XII Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | F12 |
|---|---|
| Function | Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
References
Cool D.E.,et al.J. Biol. Chem. 262:13662-13673(1987).
Schmutz J.,et al.Nature 431:268-274(2004).
Tripodi M.,et al.Nucleic Acids Res. 14:3146-3146(1986).
Cool D.E.,et al.J. Biol. Chem. 260:13666-13676(1985).
Que B.G.,et al.Biochemistry 25:1525-1528(1986).
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