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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ATP2A1 / SERCA1 Antibody (clone 1B11)   

ATP2A1 / SERCA1 Antibody (clone 1B11)

Mouse Monoclonal Antibody

     
  • WB - ATP2A1 / SERCA1 Antibody (clone 1B11) ALS13278
    Western blot of ATP2A1 expression in transfected 293T cell line by ATP2A1 monoclonal antibody,...
  • WB - ATP2A1 / SERCA1 Antibody (clone 1B11) ALS13278
    ATP2A1 monoclonal antibody, clone 1B11 Western blot of ATP2A1 expression in A-431.
  • IF - ATP2A1 / SERCA1 Antibody (clone 1B11) ALS13278
    Immunofluorescence of monoclonal antibody to ATP2A1 on A-431 cell (antibody concentration 10 ug/ml).
  • IHC - ATP2A1 / SERCA1 Antibody (clone 1B11) ALS13278
    Anti-SERCA1 antibody IHC of human heart.
  • IHC - ATP2A1 / SERCA1 Antibody (clone 1B11) ALS13278
    Anti-SERCA1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14983
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B11
Calculated MW 110kDa
Dilution ELISA (2.5 µg/ml), IF (10 µg/ml), IHC-P (5 µg/ml)
Additional Information
Gene ID 487
Other Names Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SERCA1, SR Ca(2+)-ATPase 1, 3.6.3.8, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, ATP2A1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsATP2A1 / SERCA1 Antibody (clone 1B11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP2A1
Function Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein
Tissue Location Skeletal muscle, fast twitch muscle (type II) fibers.
Research Areas
Citations (0)

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Background

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

References

Zhang Y.,et al.Genomics 30:415-424(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Daiho T.,et al.J. Biol. Chem. 276:32771-32778(2001).
Odermatt A.,et al.Hum. Genet. 106:482-491(2000).

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$ 450.00
Cat# ALS13278
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